High-Shear Rotor–Stator Wet Milling for Drug Substances: Expanding Capability with Improved Scalability
Author:
Affiliation:
1. Merck & Co. Inc., 770 Sumneytown Pike, West Point, Pennsylvania 19846, United States
2. Chemical Process Development and Commercialization, Merck & Co. Inc., 126 East Lincoln Highway, Rahway, New Jersey 07065, United States
Publisher
American Chemical Society (ACS)
Subject
Organic Chemistry,Physical and Theoretical Chemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/op4001143
Reference29 articles.
1. Milling Operations in the Pharmaceutical Industry
2. The nature of crystal disorder in milled pharmaceutical materials
3. Assessment of Milling-Induced Disorder of Two Pharmaceutical Compounds
4. Transformation of Pharmaceutical Compounds upon Milling and Comilling: The Role of Tg
5. Milling-Induced Disorder of Pharmaceuticals: One-Phase or Two-Phase System?
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