7-(1,1-Dimethylethyl)-6-(2-ethyl-2H-1,2,4- triazol-3-ylmethoxy)-3-(2-fluorophenyl)- 1,2,4-triazolo[4,3-b]pyridazine: A Functionally Selective γ-Aminobutyric AcidA (GABAA) α2/α3-Subtype Selective Agonist That Exhibits Potent Anxiolytic Activity but Is Not Sedating in Animal Models-Reference-Cited by-同舟云学术

7-(1,1-Dimethylethyl)-6-(2-ethyl-2H-1,2,4- triazol-3-ylmethoxy)-3-(2-fluorophenyl)- 1,2,4-triazolo[4,3-b]pyridazine: A Functionally Selective γ-Aminobutyric AcidA (GABAA) α2/α3-Subtype Selective Agonist That Exhibits Potent Anxiolytic Activity but Is Not Sedating in Animal Models

Published:2005-10-14 Issue:23 Volume:48 Page:7089-7092
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Carling Robert W.¹,Madin Andrew¹,Guiblin Alec¹,Russell Michael G. N.¹,Moore Kevin W.¹,Mitchinson Andrew¹,Sohal Bindi¹,Pike Andrew¹,Cook Susan M.¹,Ragan Ian C.¹,McKernan Ruth M.¹,Quirk Kathleen¹,Ferris Pushpinder¹,Marshall George¹,Thompson Sally Ann¹,Wafford Keith A.¹,Dawson Gerard R.¹,Atack John R.¹,Harrison Timothy¹,Castro José L.¹,Street Leslie J.¹

Affiliation:

1. Departments of Medicinal Chemistry, Biochemistry, and Pharmacology, Merck Sharp and Dohme Research Laboratories, Neuroscience Research Centre, Terlings Park, Eastwick Road, Harlow, Essex CM20 2QR, U.K.

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm058034a

Reference35 articles.

1. From ion currents to genomic analysis: Recent advances in GABAA receptor research

2. Distribution of GABAA and GABAB receptors in mammalian brain: Potential targets for drug development

3. GABAA/Benzodiazepine receptor heterogeneity: Neurophysiological implications

4. The GABAA receptors

5. Insensitivity to anaesthetic agents conferred by a class of GABAA receptor subunit

Cited by 52 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Design and synthesis of novel 1,2,4-triazolo[4,3-b]pyridazine derivatives with anti-cancer activity;Journal of Molecular Structure;2023-11

2. The pyridazine heterocycle in molecular recognition and drug discovery;Medicinal Chemistry Research;2023-03-15

3. Therapeutic potential of GABA_A receptor subunit expression abnormalities in fragile X syndrome;Expert Review of Precision Medicine and Drug Development;2022-01-02

4. GABAkines – Advances in the discovery, development, and commercialization of positive allosteric modulators of GABAA receptors;Pharmacology & Therapeutics;2021-11

5. Allosteric GABAA Receptor Modulators—A Review on the Most Recent Heterocyclic Chemotypes and Their Synthetic Accessibility;Molecules;2020-02-24