7-(1,1-Dimethylethyl)-6-(2-ethyl-2H-1,2,4- triazol-3-ylmethoxy)-3-(2-fluorophenyl)- 1,2,4-triazolo[4,3-b]pyridazine:  A Functionally Selective γ-Aminobutyric AcidA (GABAA) α2/α3-Subtype Selective Agonist That Exhibits Potent Anxiolytic Activity but Is Not Sedating in Animal Models

Author:

Carling Robert W.1,Madin Andrew1,Guiblin Alec1,Russell Michael G. N.1,Moore Kevin W.1,Mitchinson Andrew1,Sohal Bindi1,Pike Andrew1,Cook Susan M.1,Ragan Ian C.1,McKernan Ruth M.1,Quirk Kathleen1,Ferris Pushpinder1,Marshall George1,Thompson Sally Ann1,Wafford Keith A.1,Dawson Gerard R.1,Atack John R.1,Harrison Timothy1,Castro José L.1,Street Leslie J.1

Affiliation:

1. Departments of Medicinal Chemistry, Biochemistry, and Pharmacology, Merck Sharp and Dohme Research Laboratories, Neuroscience Research Centre, Terlings Park, Eastwick Road, Harlow, Essex CM20 2QR, U.K.

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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