Novel Tricyclic Inhibitors of IκB Kinase-Reference-Cited by-同舟云学术

Novel Tricyclic Inhibitors of IκB Kinase

Published:2009-03-06 Issue:7 Volume:52 Page:1994-2005
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Kempson James¹,Spergel Steven H.¹,Guo Junqing¹,Quesnelle Claude¹,Gill Patrice¹,Belanger Dominique¹,Dyckman Alaric J.¹,Li Tianle¹,Watterson Scott H.¹,Langevine Charles M.¹,Das Jagabandhu¹,Moquin Robert V.¹,Furch Joseph A.¹,Marinier Anne¹,Dodier Marco¹,Martel Alain¹,Nirschl David¹,Van Kirk Katy¹,Burke James R.¹,Pattoli Mark A.¹,Gillooly Kathleen¹,McIntyre Kim W.¹,Chen Laishun¹,Yang Zheng¹,Marathe Punit H.¹,Wang-Iverson David¹,Dodd John H.¹,McKinnon Murray¹,Barrish Joel C.¹,Pitts William J.¹

Affiliation:

1. Departments of Discovery Chemistry, Discovery Biology, and Metabolism and Pharmacokinetics and Synthesis and Analysis Technology Team, Bristol-Myers Squibb Research and Development, P.O. Box 4000, Princeton, New Jersey, 08543-4000

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm8015816

Reference23 articles.

1. Transcriptional profiling of IKK2/NF-κB— and p38 MAP kinasedependent gene expression in TNF-α—stimulated primary human endothelial cells

2. Role of NF-κB in immune and inflammatory responses in the gut

3. STAT3 and NF-κB Signal Pathway Is Required for IL-23-Mediated IL-17 Production in Spontaneous Arthritis Animal Model IL-1 Receptor Antagonist-Deficient Mice

4. Essential role for IKKγ/NEMO in TCR-induced IL-2 expression in Jurkat T cells

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