Identification of Interactions Involved in the Generation of Nucleophilic Reactivity and of Catalytic Competence in the Catalytic Site Cys/His Ion Pair of Papain-Reference-Cited by-同舟云学术

Identification of Interactions Involved in the Generation of Nucleophilic Reactivity and of Catalytic Competence in the Catalytic Site Cys/His Ion Pair of Papain

Published:2011-11-17 Issue:49 Volume:50 Page:10732-10742
ISSN:0006-2960
Container-title:Biochemistry
language:en
Short-container-title:Biochemistry

Author:

Hussain Syeed¹,Khan Akavish¹,Gul Sheraz¹,Resmini Marina²,Verma Chandra S.³,Thomas Emrys W.⁴,Brocklehurst Keith¹

Affiliation:

1. Laboratory of Structural and Mechanistic Enzymology, School of Biological and Chemical Sciences, Fogg Building, Queen Mary, University of London, Mile End Road, London E1 4NS, U.K.

2. School of Biological and Chemical Sciences, Joseph Priestly Building, Queen Mary, University of London, Mile End Road, London E1 4NS, U.K.

3. Bioinformatics Institute, 30, Biopolis Way, #07-01 Matrix, Singapore 138671

4. Department of Biological Sciences, University of Salford, The Crescent, Salford M5 4JW, U.K.

Publisher

American Chemical Society (ACS)

Subject

Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/bi201207z

Reference36 articles.

1. Identification of signalling and non-signalling binding contributions to enzyme reactivity. Alternative combinations of binding interactions provide for change in transition-state geometry in reactions of papain

2. The interplay of electrostatic fields and binding interactions determining catalytic-site reactivity in actinidin. A possible origin of differences in the behaviour of actinidin and papain