Identification and Characterization of 4-Methylbenzyl 4-[(Pyrimidin-2-ylamino)methyl]piperidine-1-carboxylate, an Orally Bioavailable, Brain Penetrant NR2B Selective N-Methyl-d-Aspartate Receptor Antagonist-Reference-Cited by-同舟云学术

Identification and Characterization of 4-Methylbenzyl 4-[(Pyrimidin-2-ylamino)methyl]piperidine-1-carboxylate, an Orally Bioavailable, Brain Penetrant NR2B Selective N-Methyl-d-Aspartate Receptor Antagonist

Published:2007-01-24 Issue:4 Volume:50 Page:807-819
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Liverton Nigel J.¹,Bednar Rodney A.¹,Bednar Bohumil¹,Butcher John W.¹,Claiborne Christopher F.¹,Claremon David A.¹,Cunningham Michael¹,DiLella Anthony G.¹,Gaul Stanley L.¹,Libby Brian E.¹,Lyle Elizabeth A.¹,Lynch Joseph J.¹,McCauley John A.¹,Mosser Scott D.¹,Nguyen Kevin T.¹,Stump Gary L.¹,Sun Hong¹,Wang Hao¹,Yergey James¹,Koblan Kenneth S.¹

Affiliation:

1. Departments of Medicinal Chemistry, Molecular Pharmacology, Stroke and Neurodegeneration, and Drug Metabolism, Merck Research Laboratories, West Point, Pennsylvania 19486

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm060983w

Reference41 articles.

1. Molecular biology of glutamate receptors in the central nervous system and their role in excitotoxicity, oxidative stress and aging

2. 4-Substituted-3-phenylquinolin-2(1H)-ones: Acidic and Nonacidic Glycine Site N-Methyl-d-aspartate Antagonists with in Vivo Activity

3. Glutamate in CNS disorders as a target for drug development: an update

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