Analysis of Secreted Proteins as an in vitro Model for Discovery of Liver Toxicity Markers
Author:
Affiliation:
1. U.S. Army Center for Environmental Health Research, 568 Doughten Drive, Fort Detrick, Maryland 21702
Publisher
American Chemical Society (ACS)
Subject
General Chemistry,Biochemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/pr1005668
Reference37 articles.
1. Protein biomarker discovery and validation: the long and uncertain path to clinical utility
2. Liver Disease Subcommittee of the Digestive Diseases Interagency Coordinating Committee. Action Plan for Liver Disease Research;National Institutes of Health:Bethesda, MD, 2004; pp87−93.
3. Primary Hepatocytes: Current Understanding of the Regulation of Metabolic Enzymes and Transporter Proteins, and Pharmaceutical Practice for the Use of Hepatocytes in Metabolism, Enzyme Induction, Transporter, Clearance, and Hepatotoxicity Studies
4. Multiendpoint mechanistic profiling of hepatotoxicants in HepG2/C3A human hepatoma cells and novel statistical approaches for development of a prediction model for acute hepatotoxicity
5. Phase II enzyme levels in HepG2 cells and cryopreserved primary human hepatocytes and their induction in HepG2 cells
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