Synthesis of EFdA via a Diastereoselective Aldol Reaction of a Protected 3-Keto Furanose-Reference-Cited by-同舟云学术

Synthesis of EFdA via a Diastereoselective Aldol Reaction of a Protected 3-Keto Furanose

Published:2015-02-02 Issue:4 Volume:17 Page:828-831
ISSN:1523-7060
Container-title:Organic Letters
language:en
Short-container-title:Org. Lett.

Author:

Fukuyama Kei¹,Ohrui Hiroshi²,Kuwahara Shigefumi¹

Affiliation:

1. Laboratory of Applied Bioorganic Chemistry, Graduate School of Agricultural Science, Tohoku University, Tsutsumidori-Amamiyamachi, Aoba-ku, Sendai 981-8555, Japan

2. Yokohama University of Pharmacy, 601 Matano-cho, Totsuka-ku, Yokohama 245-0066, Japan

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/ol5036535

Reference42 articles.

1. aKohgo, S.; Ohrui, H.; Kodama, E.; Matsuoka, M.; Mitsuya, H.Can. Patent CA 2502109, 2005.

2. Design, Efficient Synthesis, and Anti‐HIV Activity of 4′‐C‐Cyano‐ and 4′‐C‐Ethynyl‐2′‐deoxy Purine Nucleosides

3. 2′-deoxy′4′-C-ethynyl-2-fluoroadenosine, a nucleoside reverse transcriptase inhibitor, is highly potent against all human immunodeficiency viruses type 1 and has low toxicity

4. Development of modified nucleosides that have supremely high anti-HIV activity and low toxicity and prevent the emergence of resistant HIV mutants

5. A New Paradigm for Developing Antiviral Drugs Exemplified by the Development of Supremely High Anti-HIV Active EFdA

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