Novel P2 Tris-tetrahydrofuran Group in Antiviral Compound 1 (GRL-0519) Fills the S2 Binding Pocket of Selected Mutants of HIV-1 Protease-Reference-Cited by-同舟云学术

Novel P2 Tris-tetrahydrofuran Group in Antiviral Compound 1 (GRL-0519) Fills the S2 Binding Pocket of Selected Mutants of HIV-1 Protease

Published:2013-01-23 Issue:3 Volume:56 Page:1074-1083
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Zhang Hongmei¹,Wang Yuan-Fang¹,Shen Chen-Hsiang¹,Agniswamy Johnson¹,Rao Kalapala Venkateswara²,Xu Chun-Xiao²,Ghosh Arun K.²,Harrison Robert W.¹³,Weber Irene T.¹⁴

Affiliation:

1. Department of Biology, Georgia State University, Atlanta, Georgia 30303, United States

2. Department of Chemistry and Department of Medicinal Chemistry, Purdue University, West Lafayette, Indiana 47907, United States

3. Department of Computer Science, Molecular Basis of Disease Program, Georgia State University, Atlanta, Georgia 30303, United States

4. Department of Chemistry, Molecular Basis of Disease Program, Georgia State University, Atlanta, Georgia 30303, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm301519z

Reference41 articles.

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2. HIV/AIDS Vaccines: A Need for New Concepts?

3. HIV-1 drug resistance: can we overcome?

4. HIV-1 protease specificity of peptide cleavage is sufficient for processing of gag and pol polyproteins

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