Design, Synthesis, and SAR of a Novel Pyrazinone Series with Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitory Activity-Reference-Cited by-同舟云学术

Design, Synthesis, and SAR of a Novel Pyrazinone Series with Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitory Activity

Published:2004-11-09 Issue:6 Volume:48 Page:1910-1918
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Heeres Jan¹,de Jonge Marc R.¹,Koymans Lucien M. H.¹,Daeyaert Frits F. D.¹,Vinkers Maarten¹,Van Aken Koen J. A.¹,Arnold Eddy¹,Das Kalyan¹,Kilonda Amuri¹,Hoornaert Georges J.¹,Compernolle Frans¹,Cegla Marek¹,Azzam Rasha A.¹,Andries Koen¹,de Béthune Marie-Pierre¹,Azijn Hilde¹,Pauwels Rudi¹,Lewi Paul J.¹,Janssen Paul A. J.¹

Affiliation:

1. Center for Molecular Design, Janssen Pharmaceutica, Antwerpsesteenweg 37, B-2350 Vosselaar, Belgium, Center for Advanced Biotechnology and Medicine, and Chemistry Department, Rutgers University, 679 Hoes Lane, Piscataway, New Jersey 08854, Laboratorium voor Organische Synthese, Department of Chemistry, K.U. Leuven, Celestijnenlaan 200F, B-3001 Leuven, Belgium, Department of Organic Chemistry, Faculty of Pharmacy, Jagiellonian University, Medyczna 9, 30-688 Cracow, Poland, Department of Chemistry, Helwan...

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm040829e

Reference15 articles.

1. Structure of the binding site for nonnucleoside inhibitors of the reverse transcriptase of human immunodeficiency virus type 1.

2. Potent and selective inhibition of HIV-1 replication in vitro by a novel series of TIBO derivatives

3. Potent and highly selective human immunodeficiency virus type 1 (HIV-1) inhibition by a series of alpha-anilinophenylacetamide derivatives targeted at HIV-1 reverse transcriptase.

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