Cyclic Hydroxyamidines as Amide Isosteres: Discovery of Oxadiazolines and Oxadiazines as Potent and Highly Efficacious γ-Secretase Modulators in Vivo-Reference-Cited by-同舟云学术

Cyclic Hydroxyamidines as Amide Isosteres: Discovery of Oxadiazolines and Oxadiazines as Potent and Highly Efficacious γ-Secretase Modulators in Vivo

Published:2011-12-08 Issue:1 Volume:55 Page:489-502
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Sun Zhong-Yue¹,Asberom Theodros¹,Bara Thomas¹,Bennett Chad¹,Burnett Duane¹,Chu Inhou¹,Clader John¹,Cohen-Williams Mary¹,Cole David¹,Czarniecki Michael¹,Durkin James¹,Gallo Gioconda¹,Greenlee William¹,Josien Hubert¹,Huang Xianhai¹,Hyde Lynn¹,Jones Nicholas¹,Kazakevich Irina¹,Li Hongmei¹,Liu Xiaoxiang¹,Lee Julie¹,MacCoss Malcolm¹,Mandal Mihir B.¹,McCracken Troy¹,Nomeir Amin¹,Mazzola Robert¹,Palani Anandan¹,Parker Eric M.¹,Pissarnitski Dmitri A.¹,Qin Jun¹,Song Lixin¹,Terracina Giuseppe¹,Vicarel Monica¹,Voigt Johannes¹,Xu Ruo¹,Zhang Lili¹,Zhang Qi¹,Zhao Zhiqiang¹,Zhu Xiaohong¹,Zhu Zhaoning¹

Affiliation:

1. Department of Medicinal Chemistry, §Department of Neuroscience, ∥Department of Structural Chemistry, ⊥Department of Pharmaceutical Sciences, and #Department of Drug Metabolism and Pharmacokinetics, Schering Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm201407j

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