Construction of Drug–Polymer Thermodynamic Phase Diagrams Using Flory–Huggins Interaction Theory: Identifying the Relevance of Temperature and Drug Weight Fraction to Phase Separation within Solid Dispersions-Reference-Cited by-同舟云学术

Construction of Drug–Polymer Thermodynamic Phase Diagrams Using Flory–Huggins Interaction Theory: Identifying the Relevance of Temperature and Drug Weight Fraction to Phase Separation within Solid Dispersions

Published:2012-12-07 Issue:1 Volume:10 Page:236-248
ISSN:1543-8384
Container-title:Molecular Pharmaceutics
language:en
Short-container-title:Mol. Pharmaceutics

Author:

Tian Yiwei¹,Booth Jonathan²,Meehan Elizabeth²,Jones David S.¹,Li Shu¹,Andrews Gavin P.¹

Affiliation:

1. The Drug Delivery and Biomaterials Group, School of Pharmacy, Medical Biology Centre, Queen's University, 97 Lisburn Road, Belfast, BT9 7BL, Northern Ireland, United Kingdom

2. Pharmaceutical Development, AstraZeneca, Silk Rd Business Park, Macclesfield, SK10 2NA

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Pharmaceutical Science,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/mp300386v

Reference45 articles.

1. Improving drug solubility for oral delivery using solid dispersions

2. Amorphous pharmaceutical solids: preparation, characterization and stabilization

3. Solid dispersions as strategy to improve oral bioavailability of poor water soluble drugs

4. Supersaturating Drug Delivery Systems: The Answer to Solubility-Limited Oral Bioavailability?

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