Pyrrolo[2,3-a]carbazoles as Potential Cyclin Dependent Kinase 1 (CDK1) Inhibitors. Synthesis, Biological Evaluation, and Binding Mode through Docking Simulations
Author:
Affiliation:
1. Laboratory of Medicinal Chemistry, Laboratory of Pharmacognosy and Chemistry of Natural Products, Laboratory of Molecular Pharmacology, Department of Pharmacy, School of Health Sciences, University of Patras, GR-26500 Rion, Patras, Greece
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/jm0700666
Reference32 articles.
1. Pharmacological inhibitors of cyclin-dependent kinases
2. Mechanisms of cyclin-dependent kinase regulation: structures of cdks, their cyclin activators, and cip and INK4 inhibitors
3. Mammalian cyclin-dependent kinases
4. To cycle or not to cycle: a critical decision in cancer
5. Elevated neuronal Cdc2-like kinase activity in the Alzheimer disease brain
Cited by 41 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
1. Synthesis, Characterization, DNA-Binding, and Anticancer Activity of 7-Methoxytetrahydropyrrolo[3,4-a]carbazole-1,3-diones Derivatives with Different Hydroxyl-Alkyl Side Chains;Russian Journal of Bioorganic Chemistry;2024-06
2. Discovery of 12O—A Novel Oral Multi-Kinase Inhibitor for the Treatment of Solid Tumor;Molecules;2020-11-09
3. Small Molecule CDK Inhibitors for the Therapeutic Management of Cancer;Current Topics in Medicinal Chemistry;2020-08-20
4. Site-Selective Rh-Catalyzed C-7 and C-6 Dual C–H Functionalization of Indolines: Synthesis of Functionalized Pyrrolocarbazoles;The Journal of Organic Chemistry;2020-01-09
5. Computational Approaches Towards Kinases as Attractive Targets for Anticancer Drug Discovery and Development;Anti-Cancer Agents in Medicinal Chemistry;2019-06-27
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3