Development of a Fit-for-Purpose Large-Scale Synthesis of an Oral PARP Inhibitor-Reference-Cited by-同舟云学术

Development of a Fit-for-Purpose Large-Scale Synthesis of an Oral PARP Inhibitor

Published:2011-06-09 Issue:4 Volume:15 Page:831-840
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Wallace Debra J.¹,Baxter Carl A.¹,Brands Karel J. M.¹,Bremeyer Nadine¹,Brewer Sarah E.¹,Desmond Richard²,Emerson Khateeta M.¹,Foley Jennifer²,Fernandez Paul³,Hu Weifeng⁴,Keen Stephen P.¹,Mullens Peter¹,Muzzio Daniel³,Sajonz Peter²,Tan Lushi²,Wilson Robert D.¹,Zhou George³,Zhou Guoyue⁴

Affiliation:

1. Global Process Chemistry, Merck Sharp and Dohme Research Laboratories, Hertford Road, Hoddesdon, Hertfordshire EN11 9BU, U.K.

2. Global Process Chemistry, Merck Research Laboratories, Rahway, New Jersey 07065, United States

3. Department of Chemical Process Development and Commercialization, Merck and Co., Rahway, New Jersey, 07065, USA

4. WuXi APPTec (Shanghai) Pharmaceutical Co. Ltd., 288 Fute Zhong Road, Waigaoqiao Free Trade Zone, Shanghai 200131, China

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/op2000783

Reference23 articles.

1. The diverse biological roles of mammalian PARPS, a small but powerful family of poly-ADP-ribose polymerases

2. Poly(ADP-ribose) polymerase and the therapeutic effects of its inhibitors

3. Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase

4. Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

5. Discovery of 2-{4-[(3S)-Piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide (MK-4827): A Novel Oral Poly(ADP-ribose)polymerase (PARP) Inhibitor Efficacious in BRCA-1 and -2 Mutant Tumors

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