Synthesis, Pharmacological and Structural Characterization, and Thermodynamic Aspects of GluA2-Positive Allosteric Modulators with a 3,4-Dihydro-2H-1,2,4-benzothiadiazine 1,1-Dioxide Scaffold-Reference-Cited by-同舟云学术

Synthesis, Pharmacological and Structural Characterization, and Thermodynamic Aspects of GluA2-Positive Allosteric Modulators with a 3,4-Dihydro-2H-1,2,4-benzothiadiazine 1,1-Dioxide Scaffold

Published:2013-11-05 Issue:21 Volume:56 Page:8736-8745
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Nørholm Ann-Beth¹,Francotte Pierre²,Olsen Lars¹,Krintel Christian¹,Frydenvang Karla¹,Goffin Eric²,Challal Sylvie³,Danober Laurence³,Botez-Pop Iuliana³,Lestage Pierre³,Pirotte Bernard²,Kastrup Jette S.¹

Affiliation:

1. Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark

2. Department of Medicinal Chemistry, Drug Research Centre (CIRM), University of Liege, Avenue de l’Hôpital 1, B36, 4000 Liège, Belgium

3. Institut de Recherches Servier, Chemin de Ronde 125, F-78290 Croissy-sur-Seine, France

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm4012092

Reference30 articles.

1. Glutamate Receptor Ion Channels: Structure, Regulation, and Function

2. A Translational Approach to Evaluate the Efficacy and Safety of the Novel AMPA Receptor Positive Allosteric Modulator Org 26576 in Adult Attention-Deficit/Hyperactivity Disorder

3. AMPA receptor modulators as cognitive enhancers