Relationship of Potency and Resilience to Drug Resistant Mutations for GW420867X Revealed by Crystal Structures of Inhibitor Complexes for Wild-Type, Leu100Ile, Lys101Glu, and Tyr188Cys Mutant HIV-1 Reverse Transcriptases-Reference-Cited by-同舟云学术

Relationship of Potency and Resilience to Drug Resistant Mutations for GW420867X Revealed by Crystal Structures of Inhibitor Complexes for Wild-Type, Leu100Ile, Lys101Glu, and Tyr188Cys Mutant HIV-1 Reverse Transcriptases

Published:2007-04-19 Issue:10 Volume:50 Page:2301-2309
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Ren Jingshan¹,Nichols Charles E.¹,Chamberlain Philip P.¹,Weaver Kurt L.¹,Short Steven A.¹,Chan Joseph H.¹,Kleim Jörg-Peter¹,Stammers David K.¹

Affiliation:

1. Division of Structural Biology, The Wellcome Trust Centre for Human Genetics, Henry Wellcome Building for Genomic Medicine, University of Oxford, Roosevelt Drive, Oxford, OX3 7BN, United Kingdom, GlaxoSmithKline, Inc., 5 Moore Drive, Research Triangle Park, North Carolina 27709, and GlaxoSmithKline, Medicines Research Centre, Stevenage, Herts, SG1 2NY, United Kingdom

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm061117m

Reference43 articles.

1. New Developments in Anti-HIV Chemotherapy

2. Characterization of Highly Immunogenic p66/p51 as the Reverse Transcriptase of HTLV-III/LAV

3. Crystal Structure at 3.5 Å Resolution of HIV-1 Reverse Transcriptase Complexed with an Inhibitor

4. Crystal structure of human immunodeficiency virus type 1 reverse transcriptase complexed with double-stranded DNA at 3.0 A resolution shows bent DNA.

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