1. Department of Biochemistry, McMaster University, Hamilton, Ontario, Canada L8N 3Z5, Department of Bioinformation, Division of Bioscience, Graduate School of Science and Technology, Kobe University, Nada-ku, Rokkohdai, Kobe 657-8501, Japan, and Department of Chemical Engineering and Applied Chemistry, Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada M5S 3G9