1. Department of Environmental and Molecular Medicine, Mie University School of Medicine, 2-174, Edobashi, Tsu, Mie 514-8507, Japan, National Institute of Health Science, 1-18-1, Kamiyouga Setagaya-ku, Tokyo 158-8501, Japan, and Department of Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya, Aichi 467-8603, Japan