Bifunctional [2‘,6‘-Dimethyl-l-tyrosine]endomorphin-2 Analogues Substituted at Position 3 with Alkylated Phenylalanine Derivatives Yield Potent Mixed μ-Agonist/δ-Antagonist and Dual μ-Agonist/δ-Agonist Opioid Ligands-Reference-Cited by-同舟云学术

Bifunctional [2‘,6‘-Dimethyl-l-tyrosine]endomorphin-2 Analogues Substituted at Position 3 with Alkylated Phenylalanine Derivatives Yield Potent Mixed μ-Agonist/δ-Antagonist and Dual μ-Agonist/δ-Agonist Opioid Ligands

Published:2007-05-12 Issue:12 Volume:50 Page:2753-2766
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Li Tingyou¹,Shiotani Kimitaka¹,Miyazaki Anna¹,Tsuda Yuko¹,Ambo Akihiro¹,Sasaki Yusuke¹,Jinsmaa Yunden¹,Marczak Ewa¹,Bryant Sharon D.¹,Lazarus Lawrence H.¹,Okada Yoshio¹

Affiliation:

1. The Graduate School of Food and Medicinal Sciences and Faculty of Pharmaceutical Sciences, Kobe Gakuin University, Nishi-ku, Kobe 651-2180, Japan, Department of Biochemistry, Tohoku Pharmaceutical University, Aoba-ku, Sendai 981-8558, Japan, and Medicinal Chemistry Group, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm061238m

Reference69 articles.

1. A potent and selective endogenous agonist for the µ-opiate receptor

2. Dissociation of analgesic and rewarding effects of endomorphin-1 in rats

3. Endomorphin-1 induces antinociception without immunomodulatory effects in the rat

4. Parallel Stimulations of in Vitro and in Situ [35S]GTPγS Binding by Endomorphin 1 and DAMGO in Mouse Brains

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