1. Steacie Institute for Molecular Sciences, National Research Council of Canada, 100 Sussex Drive, Ottawa, Canada K1A 0R6, Department of Chemistry, University of Ottawa, 10 Marie-Curie, Ottawa, Canada K1N 6N5, and Department of Biochemistry, Microbiology and Immunology and Ottawa Institute of Systems Biology, University of Ottawa, Health Sciences Campus, 451 Smyth Road, Ottawa, Canada K1H 8M5