Synthesis and Activity of Largazole Analogues with Linker and Macrocycle Modification-Reference-Cited by-同舟云学术

Synthesis and Activity of Largazole Analogues with Linker and Macrocycle Modification

Published:2008-08-16 Issue:18 Volume:10 Page:4021-4024
ISSN:1523-7060
Container-title:Organic Letters
language:en
Short-container-title:Org. Lett.

Author:

Ying Yongcheng¹,Liu Yanxia¹,Byeon Seong Rim¹,Kim Hyoungsu¹,Luesch Hendrik¹,Hong Jiyong¹

Affiliation:

1. Department of Chemistry, Duke University, Durham, North Carolina 27708, and Department of Medicinal Chemistry, University of Florida, Gainesville, Florida 32610

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/ol801532s

Reference28 articles.

1. Structure and Activity of Largazole, a Potent Antiproliferative Agent from the Floridian Marine Cyanobacterium Symploca sp.

2. Total Synthesis and Molecular Target of Largazole, a Histone Deacetylase Inhibitor

3. During review of this manuscript, four other syntheses have appeared in the literature confirming our biological data reported in ref2, see:

4. A Concise Total Synthesis of Largazole, Solution Structure, and Some Preliminary Structure Activity Relationships

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