1. Departments of Pharmacology, Clinical Pharmacology, Medical Pharmacology, and Nutrition, Institute of Health Biosciences, The University of Tokushima Graduate School, 1-78-1 Sho-machi, Tokushima 770-8505, Japan; Departments of Clinical Pharmacy and Pediatrics, Tokushima University Hospital, 2-50-1 Kuramoto, Tokushima 770-8503, Japan; and Medical Pharmacology, The University of Tokushima School of Dentistry, 3-18-15 Kuramoto, Tokushima 770-8503, Japan