1. School of Pharmaceutical Sciences, Health Sciences University of Hokkaido, Ishikari-Tobetsu, Hokkaido 061-0293, Japan, Faculty of Pharmaceutical Sciences, Hiroshima International University, Hirokoshingai, Kure, Hiroshima 737-0112, Japan, and Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University, Fukuyama, Hiroshima 729-0292, Japan