1. Departament de Farmacologia, Facultat de Farmàcia, Universitat de València, Av. V. Andrés Estellés s/n, 46100 Burjassot, Valencia, Spain, and Department of Pharmaceutical Sciences, University of Strathclyde, Strathclyde Institute for Biomedical Sciences Building, 27 Taylor Street, Glasgow G4 0NR, Scotland, United Kingdom