Design of Novel Rho Kinase Inhibitors Using Energy Based Pharmacophore Modeling, Shape-Based Screening, in Silico Virtual Screening, and Biological Evaluation-Reference-Cited by-同舟云学术

Design of Novel Rho Kinase Inhibitors Using Energy Based Pharmacophore Modeling, Shape-Based Screening, in Silico Virtual Screening, and Biological Evaluation

Published:2014-10-09 Issue:10 Volume:54 Page:2876-2886
ISSN:1549-9596
Container-title:Journal of Chemical Information and Modeling
language:en
Short-container-title:J. Chem. Inf. Model.

Author:

Mishra Ram Kumar¹,Alokam Reshma¹,Singhal Sarthak Mohan¹,Srivathsav Geethasai¹,Sriram Dharamarajan¹,Kaushik-Basu Neerja²,Manvar Dinesh²,Yogeeswari Perumal¹

Affiliation:

1. Computer-Aided Drug Design Lab, Department of Pharmacy, Birla Institute of Technology & Science−Pilani, Hyderabad Campus, Jawahar Nagar, Hyderabad−500078, Andhra Pradesh, India

2. Department of Microbiology, Biochemistry and Molecular Genetics, Rutgers, The State University of New Jersey, New Jersey Medical School, 185 South Orange Avenue, Newark, New Jersey 07103, United States

Funder

Council of Scientific and Industrial Research

Publisher

American Chemical Society (ACS)

Subject

Library and Information Sciences,Computer Science Applications,General Chemical Engineering,General Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/ci5004703

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1. ROCK-I and ROCK-II, two isoforms of Rho-associated coiled-coil forming protein serine/threonine kinase in mice

2. Rho–Rho-kinase pathway in smooth muscle contraction and cytoskeletal reorganization of non-muscle cells

3. Role of RhoA, mDia, and ROCK in Cell Shape-dependent Control of the Skp2-p27 Pathway and the G1/S Transition