Chemoenzymatic Process for the Preparation of (S)-7-((tert-Butyldiphenylsilyl)oxy)hept-1-yn-4-ol in a Continuous Packed-Bed Reactor, a Key Intermediate for Eribulin Synthesis-Reference-Cited by-同舟云学术

Chemoenzymatic Process for the Preparation of (S)-7-((tert-Butyldiphenylsilyl)oxy)hept-1-yn-4-ol in a Continuous Packed-Bed Reactor, a Key Intermediate for Eribulin Synthesis

Published:2020-09-22 Issue:11 Volume:24 Page:2657-2664
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Krishna Avula Shiva¹²,Basetty Shalini¹²,Nasam Rajesh¹²,Ralte Samuel L.¹²,Reddy Chada Raji¹²^ORCID,Sudhakar Gangarajula¹²^ORCID,Pabbaraja Srihari¹²^ORCID,Chandrasekhar Srivari¹²^ORCID,Mainkar Prathama S.¹²,Kumaraguru Thenkrishnan¹²^ORCID,Ghosh Subhash¹²^ORCID

Affiliation:

1. Department of Organic Synthesis and Process Chemistry, CSIR-Indian Institute of Chemical Technology, Hyderabad 500 007, India

2. Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201 002, India

Funder

Council of Scientific and Industrial Research

Department of Science and Technology, Ministry of Science and Technology

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.0c00308

Reference40 articles.

1. aBrian, A.; Charles, E. C.; Francis, G. F. Intermediates for the Preparation of Halichondrin B. Patent WO2005118565A1, 2005.

2. bCharles, C.; Atsushi, E.; Francis, F.; Jing, L. Intermediates and Methods for the Synthesis of Halichondrin B Analogs. Patent WO2009046308A1, 2009.

3. cKazato, I.; Kubota, M.; Kayano, A.; Tagami, K. Novel Intermediate for Halichondrin B analog Synthesis and Novel Desulfonylation Reaction Used for the Intermediate. Patent WO2009064029A1, 2009.

4. dHu, Y. Halichondrin B Analogs. Patent WO2009124237A1, 2009.

5. eBruce, A. L.; Monica, H. P.; Boris, M. S.; Murray, J. T.; Melvin, J. Y.; Wanjun, Z. Macrocyclic Analogs and Methods of Their Use and Preparation. US patent 6214865B1, 2001.

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