Development and Scale-Up of a Continuous Reaction for Production of an Active Pharmaceutical Ingredient Intermediate
Author:
Affiliation:
1. Process Research and Development, Merck & Co., Inc., P.O. Box 2000, Rahway, New Jersey 07065, United States
Publisher
American Chemical Society (ACS)
Subject
Organic Chemistry,Physical and Theoretical Chemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.8b00192
Reference21 articles.
1. The synthesis of active pharmaceutical ingredients (APIs) using continuous flow chemistry
2. Development of a Continuous Plug Flow Process for Preparation of a Key Intermediate for Brivanib Alaninate
3. Development and Scale-up of a Flow Chemistry Lithiation–Borylation Route to a Key Boronic Acid Starting Material
4. Development of an Intermittent-Flow Enantioselective Aza-Henry Reaction Using an Arylnitromethane and Homogeneous Brønsted Acid–Base Catalyst with Recycle
5. Safe, Convenient ortho-Claisen Thermal Rearrangement Using a Flow Reactor
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