Development of a Safe and Practical Synthesis of Enantiomerically Pure (S)- and (R)-N-Boc-3-(Trifluoromethyl)piperazines Enabled by Aza-Michael Addition of Optically Pure 4-Phenyl-2-Oxazolidinone to 3,3,3-Trifluoro-1-Nitropropene-Reference-Cited by-同舟云学术

Development of a Safe and Practical Synthesis of Enantiomerically Pure (S)- and (R)-N-Boc-3-(Trifluoromethyl)piperazines Enabled by Aza-Michael Addition of Optically Pure 4-Phenyl-2-Oxazolidinone to 3,3,3-Trifluoro-1-Nitropropene

Published:2024-07-30 Issue:8 Volume:28 Page:3423-3435
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Darne Chetan Padmakar¹,Li Ning¹,Smith Daniel²,Zhang Shasha³^ORCID,Neithnadka Premsai Rai⁴,Silamkoti Arundutt⁴,Arumugam Arunachalam⁴,Gupta Anuradha⁴^ORCID,Hong Zhenqiu²,Krishnananthan Subramaniam²,Wang Bei²,Zhao Rulin²,Yip Shiuhang²,Wu Dauh-Rurng²,Kempson James²^ORCID,Mortensen Deborah S.⁵^ORCID,Mathur Arvind²,Li Jianqing¹^ORCID

Affiliation:

1. Small Molecule Drug Discovery, Bristol Myers Squibb Research and Early Development, Cambridge, Massachusetts 02141, United States

2. Small Molecule Drug Discovery, Bristol Myers Squibb Research and Early Development, Princeton, New Jersey 08543-4000, United States, PO Box 4000

3. Process Hazard Evaluation, Chemical Process Development, Bristol Myers Squibb, New Brunswick, New Jersey 08901, United States

4. Department of Discovery Synthesis, Biocon Bristol Myers Squibb Research Center (BBRC), Bangalore 560099, India

5. Bristol Myers Squibb, San Diego, California 92121, United States

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.4c00289

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