A Facile Route of Synthesis for Making Flibanserin-Reference-Cited by-同舟云学术

A Facile Route of Synthesis for Making Flibanserin

Published:2016-08-12 Issue:9 Volume:20 Page:1576-1580
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Yang Feipu¹²,Wu Chunhui³,Li Zhiqiang³,Tian Guanghui³,Wu Jianzhong³,Zhu Fuqiang³,Zhang Jian³,He Yang¹,Shen Jingshan¹

Affiliation:

1. CAS Key Laboratory for Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China

2. University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing 100049, China

3. Topharman Shanghai Co., Ltd., 1088 Chuansha Road, Shanghai 201209, China

Funder

Ministry of Science and Technology of the People's Republic of China

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.6b00108

Reference12 articles.

1. Flibanserin: First Global Approval

2. Flibanserin for the treatment of hypoactive sexual desire disorder in premenopausal women

3. Bietti, G.; Borsini, F.; Turconi, M.; Giraldo, E.; Bignotti, M.For treatment of central nervous system disorders. U.S. Patent 5,576,318, 1996.

4. Mohan Rao, D.; Krishna Reddy, P.; Venkat Reddy, B.Preparing benzoimidazol-2-one compound, useful to prepare flibanserin, comprises reacting benzoimidazol-2-one compound with 2-(2-hydroxy-ethylamino)-ethanol to give (bis-(hydroxy-ethyl)-amino)-ethyl-benzoimidazol-2-one compound. PCT. Int.WO2,010,128,516, 2010.5.

5. Synthesis of 1-alkyl and 1,3-dialkyl-2-benzimidazolones from 1-alkenyl-2-benzimidazolones using phase-transfer catalysis technique

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