Use of Lipase Catalytic Resolution in the Preparation of Ethyl (2S,5R)-5-((Benzyloxy)amino)piperidine-2-carboxylate, a Key Intermediate of the β-Lactamase Inhibitor Avibactam-Reference-Cited by-同舟云学术

Use of Lipase Catalytic Resolution in the Preparation of Ethyl (2S,5R)-5-((Benzyloxy)amino)piperidine-2-carboxylate, a Key Intermediate of the β-Lactamase Inhibitor Avibactam

Published:2018-11-05 Issue:12 Volume:22 Page:1738-1744
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Wang Tao¹²,Du Liang-Dong³,Wan Ding-jian³,Li Xiang³,Chen Xin-Zhi²^ORCID,Wu Guo-Feng¹^ORCID

Affiliation:

1. Research &Development Center, Zhejiang Medicine Co., Ltd, 59 East Huangcheng Road, Xinchang, Zhejiang 312500, P. R. China

2. Key Laboratory of Biomass Chemical Engineering of Ministry of Education, Zhejiang University, 38 Zhejiang University Road, Xihu District, Hangzhou 310007, P. R. China

3. Shanghai Laiyi Center for Biopharmaceuticals R&D, 5B, Building 8 200 Niudun Road Pudong District, Shanghai 201203, P. R. China

Funder

Zhejiang University

Zhejiang Province

Zhejiang Medicine Co., Ltd.

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.8b00173

Reference36 articles.

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2. Aszodi, J.; Fromentin, C.; Lampilas, M.; Rowland, D. Novel heterocyclic compounds which are active as inhibitors of beta-lactamases. PCT Int. Appl. WO/2003063864 A2, Aug 7, 2003.

3. Avibactam is a covalent, reversible, non- -lactam -lactamase inhibitor

4. Ceftazidime-Avibactam: a Novel Cephalosporin/β-lactamase Inhibitor Combination

5. Mechanistic Studies of the Inactivation of TEM-1 and P99 by NXL104, a Novel Non-β-Lactam β-Lactamase Inhibitor

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