Racemic Synthesis of a Key 1,4-Dihydro-2<i>H</i>-spiro[isoquinoline-3,4′-piperidin]-3′-ol Building Block-Reference-Cited by-同舟云学术

Racemic Synthesis of a Key 1,4-Dihydro-2H-spiro[isoquinoline-3,4′-piperidin]-3′-ol Building Block

Published:2022-11-08 Issue:11 Volume:26 Page:3034-3041
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Candito David A.¹^ORCID,Martinot Theodore A.¹^ORCID,Su Jing²,Saurí Josep³,Lam Yu-hong⁴^ORCID,Joyce Leo A.⁵^ORCID,Silverman Steven M.¹^ORCID,Sloman David L.⁶^ORCID,Maddess Matthew L.¹^ORCID,Machacek Michelle R.⁶

Affiliation:

1. Process Research and Development, Merck & Co., Inc., Boston, Massachusetts 02115, United States

2. Process Research and Development, Merck & Co., Inc., Rahway, New Jersey 07065, United States

3. Process and Analytical Research and Development, Merck & Co., Inc., Boston, Massachusetts 02115, United States

4. Computational and Structural Chemistry, Merck & Co., Inc., Rahway, New Jersey 07065, United States

5. Analytical Enabling Technologies, Merck & Co., Inc., Rahway, New Jersey 07065, United States

6. Discovery Chemistry, Merck & Co., Inc., Boston, Massachusetts 02115, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.2c00121

Reference20 articles.

1. The Atom Economy—A Search for Synthetic Efficiency

2. Redox Economy in Organic Synthesis

3. Aziridines and Epoxides in Organic Synthesis

4. Remarkable switch of regioselectivity in epoxide ring opening of 3-benzyl-7-oxa-3-azabicyclo[4.1.0]heptane with amines: practical synthesis of trans-4-amino-3-hydroxypiperidines and trans-3-amino-4-hydroxypiperidines

5. High regiocontrol in the nucleophilic ring opening of 1-aralkyl-3,4-epoxypiperidines with amines—a short-step synthesis of 4-fluorobenzyltrozamicol and novel anilidopiperidines

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