Development of a Continuous Flow Process for a Matteson Reaction: From Lab Scale to Full-Scale Production of a Pharmaceutical Intermediate-Reference-Cited by-同舟云学术

Development of a Continuous Flow Process for a Matteson Reaction: From Lab Scale to Full-Scale Production of a Pharmaceutical Intermediate

Published:2019-04-24 Issue:5 Volume:23 Page:1069-1077
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Stueckler Clemens¹,Hermsen Peter²,Ritzen Bas²,Vasiloiu Maria¹,Poechlauer Peter¹,Steinhofer Stefan¹,Pelz Andreas¹,Zinganell Christopher¹,Felfer Ulfried¹,Boyer Serge³,Goldbach Michel²,de Vries André²,Pabst Thomas⁴,Winkler Georg⁴,LaVopa Vito⁵,Hecker Scott³,Schuster Christian¹^ORCID

Affiliation:

1. Patheon Austria GmbH, Sankt-Peter Straße 25, A-4020 Linz, Austria

2. InnoSyn B.V., Urmonderbaan 22, 6167 RD Geleen, Netherlands

3. Qpex Biopharma, Inc., 6275 Nancy Ridge Drive, San Diego, California 92121, United States

4. Patheon Regensburg GmbH, Donaustaufer Strasse 378, 93055 Regensburg, Germany

5. Melinta Therapeutics, 44 Whippany Road, Suite 280, Morristown, New Jersey 07960, United States

Funder

U.S. Department of Health and Human Services

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.8b00340

Reference16 articles.

1. Scale-Up of Flow Processes in the Pharmaceutical Industry

2. Applications of Flow Chemistry in Drug Development: Highlights of Recent Patent Literature

3. Discovery of a Cyclic Boronic Acid β-Lactamase Inhibitor (RPX7009) with Utility vs Class A Serine Carbapenemases

4. Eisenman, T. FDA approves new antibacterial drug, August 29, 2017. https://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm573955.htm.

5. Homologation of boronic esters to .alpha.-chloro boronic esters

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