Synthesis of Tofogliflozin as an SGLT2 Inhibitor via Construction of Dihydroisobenzofuran by Intramolecular [4 + 2] Cycloaddition-Reference-Cited by-同舟云学术

Synthesis of Tofogliflozin as an SGLT2 Inhibitor via Construction of Dihydroisobenzofuran by Intramolecular [4 + 2] Cycloaddition

Published:2019-02-21 Issue:4 Volume:23 Page:548-557
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Murakata Masatoshi¹^ORCID,Kawase Akira¹,Kimura Nobuaki¹,Ikeda Takuma¹,Nagase Masahiro¹,Koizumi Masatoshi¹,Kuwata Kazuaki¹,Maeda Kenji¹,Shimizu Hitoshi¹

Affiliation:

1. API Process Development Department, Chugai Pharmaceutical Co., Ltd., 5-5-1 Ukima, Kita-Ku, Tokyo 115-8543, Japan

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.8b00400

Reference55 articles.

1. Tofogliflozin, a Potent and Highly Specific Sodium/Glucose Cotransporter 2 Inhibitor, Improves Glycemic Control in Diabetic Rats and Mice

2. Tofogliflozin, a novel sodium-glucose co-transporter 2 inhibitor, improves renal and pancreatic function indb/dbmice

3. In Vitro–In Vivo Correlation of the Inhibition Potency of Sodium-Glucose Cotransporter Inhibitors in Rat: A Pharmacokinetic and Pharmacodynamic Modeling Approach

4. Tofogliflozin, a sodium/glucose cotransporter 2 inhibitor, attenuates body weight gain and fat accumulation in diabetic and obese animal models

5. Effect of SGLT2 inhibitors in a murine model of urinary tract infection withCandida albicans

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