Toward the Development of a Manufacturing Process for Milvexian: Scale-Up Synthesis of the Side Chain-Reference-Cited by-同舟云学术

Toward the Development of a Manufacturing Process for Milvexian: Scale-Up Synthesis of the Side Chain

Published:2023-04-03 Issue:4 Volume:27 Page:680-691
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Wagschal Simon¹^ORCID,Broggini Diego¹,Cao Trung D.C.¹,Schleiss Pascal¹,Paun Kristian¹,Steiner Jessica¹,Merk Anna-Lena¹,Harsdorf Joachim¹,Fiedler Winfried¹,Schirling Stefan¹,Hock Sven¹,Strittmatter Tobias¹,Dijkmans Jan²,Vervest Ivan²,Van Hoegaerden Tim²,Egle Brecht²,Mower Matthew P.²,Liu Zhi³,Cao Zhiyong³,He Xiaoning³,Chen Lei⁴,Qin Lei⁴,Tan Hongyu⁴,Yan Jun⁴,Cunière Nicolas Lucien⁵,Wei Carolyn S.⁵,Vuyyuru Venkata⁶,Ayothiraman Rajaram⁶,Rangaswamy Sundaramurthy⁶,Jaleel Mohamed⁶,Vaidyanathan Rajappa⁶^ORCID,Eastgate Martin D.⁵^ORCID,Klep Richard²,Benhaïm Cyril²,Vogels Ilse²,Peeters Koen²,Lemaire Sébastien²^ORCID

Affiliation:

1. Chemical Process Research and Development, Janssen Pharmaceuticals, Hochstrasse 201, Schaffhausen 8200, Switzerland

2. Chemical Process Research and Development, Janssen Pharmaceuticals, Turnhoutseweg 30, Beerse 2340, Belgium

3. Janssen (China) R&D Center, 16 F Building A, Xinyan Mansion, 65 Guiqing Road, Shanghai 200030, China

4. Changzhou SynTheAll Pharmaceutical Co., Ltd., 589 North Yulong Road, Xinbei District, Changzhou, Jiangsu 213127, China

5. Chemical Process Development, Bristol-Myers Squibb, New Brunswick, New Jersey 08903, United States

6. Chemical Development and API Supply, Biocon Bristol-Myers Squibb Research and Development Center, Bengaluru 560099, India

Funder

Janssen Research and Development

Bristol-Myers Squibb

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.2c00399

Reference30 articles.

1. Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010

2. Thrombosis: a major contributor to the global disease burden

3. Heart Disease and Stroke Statistics—2020 Update: A Report From the American Heart Association

4. Advances in Antithrombotic Therapy

5. Factor XIa Inhibitors as New Anticoagulants

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