Comparison of One-Dimensional and Two-Dimensional Population Balance Models for Optimization of a Crystallization Process for a Needle-Shaped Active Pharmaceutical Ingredient-Reference-Cited by-同舟云学术

Comparison of One-Dimensional and Two-Dimensional Population Balance Models for Optimization of a Crystallization Process for a Needle-Shaped Active Pharmaceutical Ingredient

Published:2022-03-28 Issue:4 Volume:26 Page:1094-1105
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Rosenbaum Tamar¹^ORCID,Mbachu Victoria¹,Mitchell Niall Anthony²,Gamble John Francis³,Cho Patricia⁴,Engstrom Joshua D.¹^ORCID

Affiliation:

1. Drug Product Science and Technology, Bristol-Myers Squibb, 1 Squibb Drive, New Brunswick, New Jersey 08903, United States

2. Process Systems Enterprise (PSE) − A Siemens Business, 6th Floor East, 26-28 Hammersmith Grove, London W6 7HA, United Kingdom

3. Drug Product Science and Technology, Bristol-Myers Squibb, Moreton CH46 1QW, United Kingdom

4. Chemical and Synthetic Development, Bristol-Myers Squibb, 1 Squibb Drive, New Brunswick, New Jersey 08903, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.1c00344

Reference60 articles.

1. Perspectives on the Current State, Challenges, and Opportunities in Pharmaceutical Crystallization Process Development

2. Process analytical technology-based (PAT) model simulations of a combined cooling, seeded and antisolvent crystallization of an active pharmaceutical ingredient (API)

3. Crystals, crystal growth, and nucleation

4. Considerations on the crystallization modeling: Population balance solution

5. Population Balance Model Development Verification and Validation of Cooling Crystallization of Carbamazepine

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