Initial Route Scouting and Final Process Development for the Multi-Kg Production of 3-Fluoro-6-methoxyquinoline from <i>p</i>-Anisidine and 2-Fluoromalonic Acid-Reference-Cited by-同舟云学术

Initial Route Scouting and Final Process Development for the Multi-Kg Production of 3-Fluoro-6-methoxyquinoline from p-Anisidine and 2-Fluoromalonic Acid

Published:2022-01-20 Issue:2 Volume:26 Page:347-357
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Schäfer Gabriel¹^ORCID,Fleischer Tony¹,Blumer Nicole¹,Udry Megan¹,Reber Stefan¹,Stansfield Ian²,Liu Yuanhua²,Li Yan²,Li Pixu²

Affiliation:

1. Chemistry Process R&D, Idorsia Pharmaceuticals Ltd., Hegenheimermattweg 91, CH-4123 Allschwil, Switzerland

2. Chiral Quest (Suzhou) Co., Limited, 268 ChangAn Road, Wujiang, Suzhou, Jiangsu 215200, China

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.1c00414

Reference14 articles.

1. Hubschwerlen, C.; Rueedi, G.; Surivet, J.P.; Zumbrunn, C. (Actelion Pharmaceuticals Ltd. Switzerland). 4-(1-amino-ethyl)-cyclohexylamine derivatives. U.S. Patent 20,100,029,623 A1, 2010.

2. Über aromatische Fluorverbindungen, I.: Ein neues Verfahren zu ihrer Darstellung

3. El-Ahmad, Y.; Leconte, J.P.; Malpart, J.; Mignani, S.; Mutti, S.; Tabart, M. (Aventis Pharmeceuticals Inc. USA). Novel Process for preparing 3-fluoroquinolines. WO 2005049575 A1, 2005.

4. A One-Pot Diazotation–Fluorodediazoniation Reaction and Fluorine Gas for the Production of Fluoronaphthyridines

5. Where Does the Fluorine Come From? A Review on the Challenges Associated with the Synthesis of Organofluorine Compounds

Cited by 1 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Visible light-driven dehydrocoupling of thiols to disulfides and H2 evolution over PdS-decorated ZnIn2S4 composites;Chinese Journal of Catalysis;2023-08