An Enantioselective Hydrogenation of an Alkenoic Acid as a Key Step in the Synthesis of AZD2716-Reference-Cited by-同舟云学术

An Enantioselective Hydrogenation of an Alkenoic Acid as a Key Step in the Synthesis of AZD2716

Published:2016-01-07 Issue:2 Volume:20 Page:262-269
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Karlsson Staffan¹,Sörensen Henrik¹,Andersen Sören M.¹,Cruz Angele¹,Ryberg Per²

Affiliation:

1. CVMD iMed, Medicinal Chemistry, AstraZeneca R&D Mölndal, SE-431 83 Mölndal, Sweden

2. SP Process Development, Box 36, SE-151 21 Södertälje, Sweden

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.5b00382

Reference22 articles.

1. Giordanetto, F.Discovery of (2R)-3-[3-(5-benzyl-2-carbamoylphenyl)phenyl]-2-methylpropanoic acid (AZD2716): a novel, potent secreted phospholipase A2 inhibitor for the treatment of coronary artery cardiovascular disease. Manuscript in preparation.

2. Use of the SPhos Ligand to Suppress Racemization in Arylpinacolboronate Ester Suzuki Couplings Involving α-Amino Acids. Synthesis of Biaryl Derivatives of 4-Hydroxyphenylglycine, Tyrosine, and Tryptophan

3. Cross-coupling reactions via organoboranes

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