Development of a Concise Process for the Synthesis of the Azaindazole Core of the CD73 Inhibitor AB680-Reference-Cited by-同舟云学术

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Development of a Concise Process for the Synthesis of the Azaindazole Core of the CD73 Inhibitor AB680

Published:2023-04-19 Issue:5 Volume:27 Page:945-953
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Yin Xiaopeng¹^ORCID,Song Zhiguo Jake¹^ORCID,Kalisiak Jaroslaw¹,Tripp Jonathan C.²,Lei Xiao³,Li Hongfeng³,Zhang Aimin¹^ORCID

Affiliation:

1. Small Molecule Pharmaceutical Development and Manufacturing, Arcus Biosciences, Hayward, California 94545, United States

2. Process Chemistry Research and Development, Gilead Sciences, Inc., Foster City, California 94404, United States

3. Pharmaron Xi’an Co., Ltd, Xi’an, Shanxi 710018, China

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.3c00056

Reference23 articles.

1. Extracellular adenosine triphosphate and adenosine in cancer

2. CD73-generated extracellular adenosine in chronic lymphocytic leukemia creates local conditions counteracting drug-induced cell death

3. CD73 promotes anthracycline resistance and poor prognosis in triple negative breast cancer

4. A Metabolic Immune Checkpoint: Adenosine in Tumor Microenvironment

5. Differential ectonucleotidase expression in human bladder cancer cell lines

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1. Epigrammatic Review on Heterocyclic Moiety Pyrazole: Applications and Synthesis Routes;Mini-Reviews in Organic Chemistry;2024-09

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