Synthesis of Rovafovir Etalafenamide (Part III): Evolution of the Synthetic Process to the Phosphonamidate Fragment-Reference-Cited by-同舟云学术

Synthesis of Rovafovir Etalafenamide (Part III): Evolution of the Synthetic Process to the Phosphonamidate Fragment

Published:2021-05-05 Issue:5 Volume:25 Page:1247-1262
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Ambrosi Andrea¹^ORCID,Bringley Dustin A.¹,Calimsiz Selcuk²,Garber Jeffrey A. O.²,Huynh Huy²,Mohan Sankar²,Sarma Keshab¹,Shen Jinyu²,Curl Jonah²,Kwong Bernard²,Lapina Olga¹,Leung Edmund²,Lin Lennie²,Martins Andrew²,McGinitie Teague³,Phull Jaspal²,Roberts Ben¹,Rosario Mary²,Shi Bing¹,Standley Eric A.¹,Wang Li²,Wang Xueqing²,Yu Guojun²

Affiliation:

1. Process Chemistry, Gilead Sciences Inc., 333 Lakeside Drive, Foster City, California 94404, United States

2. Process Development, Gilead Alberta ULC, 1021 Hayter Road NW, Edmonton, Alberta T6S 1A1, Canada

3. Analytical Chemistry, Gilead Alberta ULC, 1021 Hayter Road NW, Edmonton, Alberta T6S 1A1, Canada

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.0c00428

Reference49 articles.

1. Medicinal Chemistry of Nucleoside Phosphonate Prodrugs for Antiviral Therapy

2. Synthesis of Nucleoside Phosphate and Phosphonate Prodrugs

3. Phosphoramidates and phosphonamidates (ProTides) with antiviral activity

4. The ProTide Prodrug Technology: From the Concept to the Clinic

5. Synthesis and evaluation of novel amidate prodrugs of PMEA and PMPA

Cited by 5 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Practical Synthesis of Tenofovir Alafenamide Fumarate Inspired by New Retrosynthetic Disconnection Featuring a Novel Carbon–Phosphorus Bond Construction Methodology;Organic Process Research & Development;2023-05-19

2. Crystallization: A Tool for Asymmetric Synthesis and Isolation;Reference Module in Chemistry, Molecular Sciences and Chemical Engineering;2022

3. Rovafovir Etalafenamide (Part III): Synthesis of the Phosphonamidate Fragment;Synfacts;2021-07-20

4. Synthesis of Rovafovir Etalafenamide (Part I): Active Pharmaceutical Ingredient Process Development, Scale-Up, and Impurity Control Strategy;Organic Process Research & Development;2021-05-09

5. Synthesis of Rovafovir Etalafenamide (Part IV): Evolution of the Synthetic Process to the Fluorinated Nucleoside Fragment;Organic Process Research & Development;2021-05-07