Synthesis of Fingolimod Employing Regioselective Aziridine Ring-Opening Reaction as a Key Step
Author:
Affiliation:
1. API Synthesis Development, Zentiva, k.s., U Kabelovny 130, 102 37, Prague 10, Czech Republic
Publisher
American Chemical Society (ACS)
Subject
Organic Chemistry,Physical and Theoretical Chemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.1c00248
Reference50 articles.
1. Design, synthesis, and structure-activity relationships of 2-substituted-2-amino-1,3-propanediols: Discovery of a novel immunosuppressant, FTY720
2. Adachi, K.; Mishina, T.; Obara, T. Novel process for producing 2-amino-2-(2-(4octylphenyl) ethyl) propane-1,3-diol. Patent JP11310556, 1998.
3. FTY720 Story. Its Discovery and the following Accelerated Development of Sphingosine 1-Phosphate Receptor Agonists as Immunomodulators Based on Reverse Pharmacology
4. Fingolimod is a potential novel therapy for multiple sclerosis
5. Iron-Catalyzed Cross-Coupling Reactions. A Scalable Synthesis of the Immunosuppressive Agent FTY720
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