Reaction of Irbesartan with Nitrous Acid Produces Irbesartan Oxime Derivatives, rather than N-Nitrosoirbesartan

Author:

Lin Jinsheng1,Zhou Qiang1,Jia Ru1,Liu Wentao1,Hou Huacui1,Ma Jian1,Li Dan1,Chen Nuo1,Chen Wenbin1,Ye Jian1,Hu Wenping1,Zhu Wenquan1,Li Min12ORCID

Affiliation:

1. Center of Excellence for Modern Analytical Technologies (CEMAT), Huahai Pharmaceutical Co., Ltd., Xunqiao, Linhai 317024, Zhejiang, P. R. China

2. Huahai US, Inc., 700 Atrium Drive, Somerset, New Jersey 08873, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Reference24 articles.

1. Quantitative Analysis of Irbesartan in Pharmaceuticals and Human Biological Fluids by Voltammetry

2. Development, evaluation and characterization of surface solid dispersion for solubility and dispersion enhancement of irbesartan

3. Carcinogenesis in rats by nitrosodimethylamine and other nitrosomethylalkylamines at low doses

4. FDA Announces Voluntary Recall of Several Medicines Containing Valsartan Following Detection of An Impurity, 2018. https://www.fda.gov/news-events/press-announcements/fda-announces-voluntary-recall-several-medicines-containing-valsartan-following-detection-impurity (accessed December 07, 2021).

5. aStatement Alerting Patients and Health Care Professionals of NDMA Found in Samples of Ranitidine, 2019, https://www.fda.gov/news-events/press-announcements/statement-alerting-patients-and-health-care-professionals-ndma-found-samples-ranitidine.

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