Development of a Novel Process for the Preparation of the Anti-Inflammatory Drug Betamethasone Sodium Phosphate

Author:

Bova Antonio1,Saba Manuela1,Novelli Stefano1,Pecora Fabio1ORCID

Affiliation:

1. Steroid S.p.A., Viale Spagna, 156/160, Cologno Monzese, Milan 20093, Italy

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Reference40 articles.

1. FDA approved drug products: Celestone Soluspan (betamethasone sodium phosphate and betamethasone acetate) injectable suspension. https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/014602s062lbl.pdf (accessed 20 Oct, 2022).

2. Orange book FDA. https://www.accessdata.fda.gov/scripts/cder/ob/search_product.cfm (accessed 20 Oct, 2022).

3. Betamethasone Sodium Phosphate: Summary Report; University of Maryland School of Pharmacy, 2021. http://hdl.handle.net/10713/17490 (accessed 20 Oct, 2022).

4. The use of other conventional phosphorylating agents such as phosphorous pentachloride, phosphoric acid and polyphosphoric acid resulted unsatisfactory for the preparation of 21-phosphates of corticosteroid as reported in Steroid compounds, Takeda Chemical Industries Ltd (applicant). GB 1148453 A, 1969.

5. Steroid compounds, Takeda Chemical Industries Ltd (applicant). GB 1148453 A, 1969.

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