Accelerated Development of a Scalable Ring-Closing Metathesis to Manufacture AMG 176 Using a Combined High-Throughput Experimentation and Computational Modeling Approach-Reference-Cited by-同舟云学术

Accelerated Development of a Scalable Ring-Closing Metathesis to Manufacture AMG 176 Using a Combined High-Throughput Experimentation and Computational Modeling Approach

Published:2020-11-25 Issue:3 Volume:25 Page:442-451
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

St-Pierre Gabrielle¹^ORCID,Cherney Alan H.¹^ORCID,Chen Wencan¹,Dong Xiaofei²,Dornan Peter K.³^ORCID,Griffin Daniel J.³,Houk K. N.²^ORCID,Lin Janice B.²^ORCID,Osgood Stephen¹,Silva Elipe Maria V.¹^ORCID,Timmons Heath C.¹,Xie Yong¹,Tedrow Jason S.¹^ORCID,Thiel Oliver R.³,Smith Austin G.¹^ORCID

Affiliation:

1. Drug Substance Technologies Process Development, Amgen Inc., 1 Amgen Center Drive, Thousand Oaks, California 91320, United States

2. Department of Chemistry and Biochemistry, University of California, 405 Hilgard Avenue, Los Angeles, California 90095-1569, United States

3. Drug Substance Technologies Process Development, Amgen Inc., Cambridge, Massachusetts 02141, United States

Funder

Amgen

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.0c00416

Reference33 articles.

1. Olefin metathesis

2. Metathesis Reactions in Total Synthesis

3. Evolution of Catalytic Stereoselective Olefin Metathesis: From Ancillary Transformation to Purveyor of Stereochemical Identity

4. Olefin Metathesis at the Dawn of Implementation in Pharmaceutical and Specialty-Chemicals Manufacturing

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