Efficiency and Sustainability through Development of a Next-Generation, Commercial Synthesis of Valbenazine Ditosylate-Reference-Cited by-同舟云学术

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Efficiency and Sustainability through Development of a Next-Generation, Commercial Synthesis of Valbenazine Ditosylate

Published:2024-07-12 Issue:8 Volume:28 Page:3267-3272
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Tucker John L.¹^ORCID,Kucera David J.¹,Hettinger Don¹,Branum Shawn¹,Cochran Brian¹,Culhane Jeff¹,Zhao Lucy¹,Palmer Andrew Benjamin²^ORCID,Leeman Kyle³,Yu Stanley³^ORCID,Martin Bénédicte⁴,André Nicolas⁴,Perron Julien⁴,Comas Horacio⁴,Zhao Yuxin¹

Affiliation:

1. Neurocrine Biosciences, CMC, 12780 El Camino Real, San Diego, California 92130, United States

2. Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, California 90095, United States

3. Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States

4. Siegfried Evionnaz S.A., Route du Simplon 1, 36, CH-1902 Evionnaz, Switzerland

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.4c00148

Reference13 articles.

1. https://www.ingrezza.com.

2. US FDA. FDA approves first drug to treat tardive dyskinesia [media release]; https://www.fda.gov.

3. Valbenazine granted breakthrough drug status for treating tardive dyskinesia

4. Differences in Dihydrotetrabenazine Isomer Concentrations Following Administration of Tetrabenazine and Valbenazine

5. Absolute configuration of (+)-?-dihydrotetrabenazine, an active metabolite of tetrabenazine

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