Continuous Multiphase Flow Nitration and Cryogenic Flow Formylation: Enabling Process Development and Manufacturing of Pharmaceutical Intermediates-Reference-Cited by-同舟云学术

Continuous Multiphase Flow Nitration and Cryogenic Flow Formylation: Enabling Process Development and Manufacturing of Pharmaceutical Intermediates

Published:2021-10-28 Issue:11 Volume:25 Page:2473-2481
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Cardinal-David Benoit¹^ORCID,Harper Kaid C.¹^ORCID,Verma Anuj¹,Hanna David¹,Caspi Daniel D.¹^ORCID,Vitale Christopher¹,Bien Jeffrey T.¹,Wang Zhe¹^ORCID,Diwan Moiz¹^ORCID

Affiliation:

1. Process Research & Development, AbbVie Inc., 1 N. Waukegan Road, North Chicago, Illinois 60064, United States

Funder

AbbVie

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.1c00249

Reference22 articles.

1. Continuous flow chemistry: where are we now? Recent applications, challenges and limitations

2. Applications of Flow Chemistry in Drug Development: Highlights of Recent Patent Literature

3. The Hitchhiker’s Guide to Flow Chemistry

4. The preparation of compound 2 has been reported previously using a nitration reaction Takano, Y.; Asano, J.; Anraku, T.; Fukuchi, K. 6-substituted heteroquinoline carboxylic acid derivatives and addition salts thereof and processes for the preparation of both. U.S. Patent US6562839 B12003.

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