Continuous Multiphase Flow Nitration and Cryogenic Flow Formylation: Enabling Process Development and Manufacturing of Pharmaceutical Intermediates
Author:
Affiliation:
1. Process Research & Development, AbbVie Inc., 1 N. Waukegan Road, North Chicago, Illinois 60064, United States
Funder
AbbVie
Publisher
American Chemical Society (ACS)
Subject
Organic Chemistry,Physical and Theoretical Chemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.1c00249
Reference22 articles.
1. Continuous flow chemistry: where are we now? Recent applications, challenges and limitations
2. Applications of Flow Chemistry in Drug Development: Highlights of Recent Patent Literature
3. The Hitchhiker’s Guide to Flow Chemistry
4. The preparation of compound 2 has been reported previously using a nitration reaction Takano, Y.; Asano, J.; Anraku, T.; Fukuchi, K. 6-substituted heteroquinoline carboxylic acid derivatives and addition salts thereof and processes for the preparation of both. U.S. Patent US6562839 B12003.
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