Nucleophilic Aromatic Substitutions of 2-Halo-5-(sulfamoyl)benzoic Acids and N,O-Bis-alkylation via Phase Transfer Catalysis: Synthesis of RoRγ Inverse Agonist GSK2981278A-Reference-Cited by-同舟云学术

Nucleophilic Aromatic Substitutions of 2-Halo-5-(sulfamoyl)benzoic Acids and N,O-Bis-alkylation via Phase Transfer Catalysis: Synthesis of RoRγ Inverse Agonist GSK2981278A

Published:2019-06-03 Issue:7 Volume:23 Page:1396-1406
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Barcan Gregg A.¹,Conde Jose J.¹,Mokhallalati Mohamed K.¹,Nilson Mark G.¹,Xie Shiping¹^ORCID,Allen C. Liana²,Andemichael Yemane W.¹,Calandra Nicholas A.³,Leitch David C.⁴^ORCID,Li Ling¹,Morris Michael J.¹

Affiliation:

1. Product Development and Supply, GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, United States

2. Vertex Pharmaceuticals Inc., 50 Northern Avenue, Boston, Massachusetts 02210, United States

3. H3 Biomedicine, 300 Technology Square, Cambridge, Massachusetts 02139, United States

4. University of Victoria, P.O. Box 3065, Victoria, British Columbia, Canada V8W 3V6

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.9b00147

Reference18 articles.

1. Getting under the skin: the immunogenetics of psoriasis

2. Anti–Interleukin-17 Monoclonal Antibody Ixekizumab in Chronic Plaque Psoriasis

3. Brodalumab, an Anti–Interleukin-17–Receptor Antibody for Psoriasis

4. Development of a Topical Treatment for Psoriasis Targeting RORγ: From Bench to Skin

5. Boron Reagents in Process Chemistry: Excellent Tools for Selective Reductions

Cited by 5 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Nucleophilic Aromatic Substitution;Organic Reaction Mechanisms Series;2023-01-20

2. Assembly of (hetero)aryl thioethers via simple nucleophilic aromatic substitution and Cu-catalyzed coupling reactions with (hetero)aryl chlorides and bromides under mild conditions;Green Chemistry;2023

3. A broadly applicable quantitative relative reactivity model for nucleophilic aromatic substitution (S_NAr) using simple descriptors;Chemical Science;2022

4. A recyclable ciprofloxacin polymer ligand for copper-catalyzed coupling of (hetero)aryl halide aminations;New Journal of Chemistry;2022

5. Generation of formaldehyde and formaldehyde-d₂ for hydroxymethylations and hydroxydeuteromethylations of difluoroenolates and difluorobenzyl carbanions;Chemical Communications;2022