Development of a Quality Controllable and Scalable Process for the Preparation of 7,8-Difluoro-6,11-dihydrodibenzo[b,e]thiepin-11-ol: A Key Intermediate for Baloxavir Marboxil-Reference-Cited by-同舟云学术

Development of a Quality Controllable and Scalable Process for the Preparation of 7,8-Difluoro-6,11-dihydrodibenzo[b,e]thiepin-11-ol: A Key Intermediate for Baloxavir Marboxil

Published:2019-11-28 Issue:12 Volume:23 Page:2716-2723
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Zhou Zihong¹²^ORCID,Wang Zhongqing³¹²^ORCID,Kou Jingping¹,Wu Shuming¹,Zhang Junrong¹,Yuan Xi¹,Wu Xiwei¹,Li Chuan-hua³,Liao Gaohong¹

Affiliation:

1. HEC Research and Development Center, HEC Pharm Group, Dongguan 523871, P. R. China

2. State Key Laboratory of Anti-Infective Drug Development, Sunshine Lake Pharma Co., Ltd., Dongguan 523871, P. R. China

3. Hunan Provincial Key Laboratory of Xiangnan Rare-Precious Metals Compounds Research and Application, Xiangnan University, Chenzhou 423000, P. R. China

Funder

Natural Science Foundation of Hunan Province

State Key Laboratory of Anti-Infective Drug Development, HEC Pharm

Key Science and Technology Brainstorm Project of Dongguan

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.9b00389

Reference19 articles.

1. S-033447/S-033188, a Novel Small Molecule Inhibitor of Cap-Dependent Endonuclease of Influenza A and B Virus: In Vitro Antiviral Activity Against Clinical Strains

2. Baloxavir: First Global Approval

3. According to U.S. Food and Drug Administration (FDA). https://www.fda.gov/news-events/press-announcements/fda-approves-new-drug-treat-influenza(accessed Sept 17, 2009).

4. aMakato, K.; Kenji, T.; Toshiyuki, A.; Azusa, O.; Masayoshi, M. Substituted Polycyclic Pyridone Derivative and Prodrug Thereof. US Patent US10392406A12016.

5. bSetsuya, S.; Nobuaki, F.; Toshikatsu, M. Method for Producing Substituted Polycyclic Pyridone Derivative and Crystal of Same. WO2017221869A12017.

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