Continuous Flow Synthesis of the PARP-1/2 Inhibitor HYDAMTIQ: Synthetic Strategy, Optimization, and Green Metrics Evaluation-Reference-Cited by-同舟云学术

Continuous Flow Synthesis of the PARP-1/2 Inhibitor HYDAMTIQ: Synthetic Strategy, Optimization, and Green Metrics Evaluation

Published:2023-11-14 Issue: Volume: Page:
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Filipponi Paolo¹^ORCID,Cerra Bruno¹,Piccinno Alessandro¹,Camaioni Emidio¹^ORCID,Gioiello Antimo¹^ORCID

Affiliation:

1. Laboratory of Medicinal and Advanced Synthetic Chemistry (Lab MASC), Department of Pharmaceutical Sciences, University of Perugia, Via del Liceo 1, 06123 Perugia, Italy

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.3c00295

Reference49 articles.

1. Discovery and characterization of novel potent PARP-1 inhibitors endowed with neuroprotective properties: From TIQ-A to HYDAMTIQ

2. The expanding universe of PARP1-mediated molecular and therapeutic mechanisms

3. The multifaceted roles of PARP1 in DNA repair and chromatin remodelling

4. PARP inhibitors: Synthetic lethality in the clinic

5. Concepts and Molecular Aspects in the Polypharmacology of PARP-1 Inhibitors

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