Scalable Flow Electrochemical Alcohol Oxidation: Maintaining High Stereochemical Fidelity in the Synthesis of Levetiracetam-Reference-Cited by-同舟云学术

Scalable Flow Electrochemical Alcohol Oxidation: Maintaining High Stereochemical Fidelity in the Synthesis of Levetiracetam

Published:2021-04-19 Issue:12 Volume:25 Page:2601-2607
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Zhong Xing¹²,Hoque Md Asmaul¹,Graaf Matthew D.³,Harper Kaid C.³^ORCID,Wang Fei¹^ORCID,Genders J. David⁴,Stahl Shannon S.¹^ORCID

Affiliation:

1. Department of Chemistry, University of Wisconsin─Madison, 1101 University Avenue, Madison, Wisconsin 53706, United States

2. College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310032, P. R. China

3. Process R&D, AbbVie, 1401 Sheridan Road, North Chicago, Illinois 60064, United States

4. Electrosynthesis Company, Inc., Lancaster, New York 14086-9779, United States

Funder

AbbVie

China Scholarship Council

National Institute of General Medical Sciences

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.1c00036

Reference36 articles.

1. Levetiracetam: A Novel Antiepileptic Drug

2. Potential of Levetiracetam in Mood Disorders

3. aGobert, J., Geerts, J.P., Dodson, G. (S)-alpha-ethyl-2-oxo-1-pyrrolidineacetamide compositions. US4837223 A, 1989.

4. bGobert, J., Geerts, J.P., Bodson, G. (S)-alpha-ethyl-2-oxo-1-pyrrolidineacetamide, US4943639 A, 1990.

5. cSurtees, J.; Marmon, V.; Differding, E.; Zimmermann, V. 2-oxo-1-pyrrolidine derivatives, process for preparing them and their uses. US7217826 B2, 2007.

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