Development of an Enzymatic Process for the Synthesis of (S)-2-Chloro-1-(2,4-dichlorophenyl) Ethanol

Author:

Wei Teng-Yun1,Tang Jia-Wei1,Ni Guo-Wei1,Wang Hong-Yi1,Yi Dong2,Zhang Fu-Li1ORCID,Chen Shao-Xin1ORCID

Affiliation:

1. Shanghai Institute of Pharmaceutical Industry, China State Institute of Pharmaceutical Industry, 285 Gebaini Road, Pudong 201203, Shanghai, China

2. Department of Biotechnology & Enzyme Catalysis, Institute of Biochemistry, Felix-Hausdorff-Str.4, Greifswald D-17487, Germany

Funder

Program of Shanghai Technology Research Leader

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Reference21 articles.

1. 2013 FDA drug approvals

2. Achievement of Complete Mycological Cure by Topical Antifungal Agent NND-502 in Guinea Pig Model of Tinea Pedis

3. Inhibition of sterol 14 alpha-demethylation of Candida albicans with NND-502, a novel optically active imidazole antimycotic agent

4. Bhirud, S. B.; Bhushan, K. H.; Zhope, S. S.; Ghadigaonkar, S. G.; Singh, F.; Deshmukh, S. A.; Chand, P. Process for Preparation of Luliconazole. U.S. Patent 20170362212A1, 2017.

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