Transformation of the Manufacturing Process from Discovery to Kilogram Scale for AWZ1066S: A Highly Specific Anti-<i>Wolbachia</i> Drug Candidate for a Short-Course Treatment of Filariasis-Reference-Cited by-同舟云学术

Transformation of the Manufacturing Process from Discovery to Kilogram Scale for AWZ1066S: A Highly Specific Anti-Wolbachia Drug Candidate for a Short-Course Treatment of Filariasis

Published:2023-01-10 Issue:1 Volume:27 Page:42-53
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Hong W. David¹^ORCID,O’Neill Paul M.¹^ORCID,Taylor Mark J.²,Turner Joseph D.²,Ward Stephen A.²,Gusovsky Fabian³,Benayoud Farid⁴,Shibuguchi Nao⁵,Girish Dixit⁶,Fang Francis Gerard⁴,Talabhakthla Ravi Kumar⁶,Vaddi Anand⁶,Challa Chiranjeevi⁶,Reddy Karri Satya Ammi⁶,Kalla Vijay⁶,Srinivasa Rao Sugandham⁶,Nagireddi Durga Mahesh Kumar⁶,Patel Jayesh⁶,Khile Anil Shahaji⁶

Affiliation:

1. Department of Chemistry, University of Liverpool, L69 7ZD Liverpool, United Kingdom

2. Research Centre for Drugs and Diagnostics, Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Liverpool L3 5QA, United Kingdom

3. G2D2 Eisai Inc., 35 Cambridgepark Drive, Cambridge, Massachusetts 02140, United States

4. Eisai AiM Institute, Eisai, Inc., Andover, Massachusetts 01810, United States

5. Analytical Research, Pharmaceutical Science & Technology, CFU, Medicine Development Center, Eisai Co. Ltd., 5-1-3-Tokodai, Tsukuba-shi, Ibaraki 300-2635, Japan

6. Eisai Pharmaceuticals India Pvt. Ltd., Ramky Pharma City, (SEZ), Plot Nos.96, 97, 98,124 &126, Parawada, Visakhapatnam, Andhra Pradesh 531019, India

Funder

Medical Research Council

Global Health Innovative Technology Fund

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.2c00167

Reference16 articles.

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3. Phenotypic Evidence of Emerging Ivermectin Resistance in Onchocerca volvulus

4. World Health Organization. Ending the Neglect to Attain the Sustainable Development Goals – A Road Map for Neglected Tropical Diseases 2021–2030; 2020.

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